Folinic Acid

Active Pharmaceutical Ingredients (API)


CAS number: 58-05-9



(6RS)-Folinic acid
(6RS)-N5-Formyl-5,6,7,8-tetrahydrofolic acid


Background and use

Folinic acid is used for the preparation of concentrated, calcium free solutions of (6RS) - Sodium Folinate, suitable to be mixed and administered together with 5-Fluorouracil or oxaliplatin solutions in the cancer therapy. For details refer to the “Oncofolic“ brochure published by Medac Gesellschaft für klinische Spezialpreparate mbH, Fehlandstrasse 3, D-20354 Hamburg, the product sheet of Calcium Folinate to the general Reduced Folates chapter.


    • Active Pharmaceutical Ingredients (API)
    • Drug
    • Patent
    • DMF
    • CEP
    • Folinic Acid


Regulatory compliance

A DMF is available.

Intellectual property

  • Method of production: patent pending
  • Formulated solutions of Sodium Folinate derived from Folinic Acid are patent protected (EP 667 159 ; US 5 814 635)

Packaging information

The active ingredient is packed in double low density polyethylene bags in high density polyethylene containers up to 64 liters. Variable quantities of API up to 20kg of material per container are offered.