5-Methyl-tetrahydrofolic Acid Calcium Salt

Chemical division

Formula

CERBIOS - PHARMA SA
CAS number: 26560-38-3

 

Synonyms

(6RS)-N5-Methyl-5,6,7,8-Tetrahydrofolic Acid Calcium Salt
Calcium Mefolinate

 

Background and use

For the use of N5-Methyl-Tetrahydrofolic Acid in the oncological and nutritional field see the general Reduced Folates chapter.
A characteristic property which distinguishes N5-Methyl-Tetrahydrofolic Acid from the other reduced folates is that it can cross the blood brain barrier. This has implications for example in case of treatment of depression as shown in literature reference 8 in the general Reduced Folates chapter.

 

    • Active Pharmaceutical Ingredients (API)
    • Drug
      Substance
    • Patent
    • DMF
    • CEP
    • 5-Methyl-tetrahydrofolic Acid Calcium Salt
    • •
    • •
    • •

 

Regulatory compliance

A DMF is available.

Intellectual property

  • A method of purification of N5-Methyl-tetrahydrofolic acid calcium salt is patent protected (CH 682 665)
  • Ammonium salts of N5-Methyl-tetrahydrofolic acid are patent protected (EP 455 013)

Packaging information

The active ingredient is packed in a low density polyethylene bag in a high density polyethylene aluminium bag in high density polyethylene containers up to 64 liters. Variable quantities of API per container are available.